In a large bowl, combine the buttermilk, garlic powder, onion powder, paprika, salt, and black pepper. Add the chicken pieces and stir to coat. Cover and refrigerate for at least 1 hour, or up to overnight for best flavor.
In a shallow dish, place the flour. In another shallow dish, add the panko breadcrumbs.
Remove the chicken from the buttermilk mixture, allowing excess to drip off. Dredge each piece in flour, then dip back into the buttermilk, and finally coat with panko breadcrumbs, pressing gently to adhere.
In a large skillet, heat about 1 inch of vegetable oil over medium-high heat until it reaches 350°F.
Carefully add the breaded chicken pieces in batches, making sure not to overcrowd the pan. Fry for 3-4 minutes on each side, or until golden brown and cooked through.
Use a slotted spoon to transfer the chicken bites to a paper towel-lined plate to drain excess oil.
Serve warm with your favorite dipping sauce.